Health
New treatment destroys head and neck cancer tumours in trial

New treatment destroys head and neck cancer tumours in trial
A new cancer treatment can wipe out tumours in terminally ill head and neck cancer patients, scientists have discovered.
In a landmark trial, a cocktail of immunotherapy medications harnessed patients’ immune systems to kill their own cancer cells and prompted “a positive trend in survival”, according to researchers at the Institute of Cancer Research (ICR), London, and the Royal Marsden NHS foundation trust.
One patient, who was expected to die four years ago, spoke of the “amazing” moment nurses called him weeks after he joined the study to say his tumour had “completely disappeared”. The 77-year-old grandfather is now cancer-free and spent last week on a cruise with his wife.
Scientists found the combination of nivolumab and ipilimumab medications led to a reduction in the size of tumours in terminally ill head and neck cancer patients. In some, their cancer vanished altogether, with doctors stunned to find no detectable sign of disease.
Combining the two immunotherapy drugs could prove an effective new weapon against several forms of advanced cancer, experts believe. Results from other trials of the drug combination have previously suggested similar benefits for terminally ill kidney, skin and bowel cancer patients.
As well as boosting the long-term survival chances of patients, scientists said, the immunotherapy treatment also triggered far fewer side-effects compared with the often gruelling nature of “extreme” chemotherapy, which is the standard treatment offered to many patients with advanced cancer.
The results from the phase 3 trial, involving almost 1,000 dying head and neck cancer patients, were early and not statistically significant but were still “clinically meaningful”, the ICR said, with some patients living months or years longer and suffering fewer side effects.
“These are promising results,” Prof Kristian Helin, the ICR chief executive, told the Guardian. “Immunotherapies are kinder, smarter treatments that can bring significant benefits to patients.”
About 12,000 people in the UK are diagnosed with head and neck cancer every year and many will be diagnosed at advanced stages. There is an urgent need for better, kinder treatments for these patients that can keep them alive longer than the current standard of care.
When Barry Ambrose, 77, from Bury St Edmunds, was diagnosed with throat cancer in 2017, he was told that it had already spread to his lungs – and that hospital palliative care was his only option.
But in a turn of events that saved his life, Ambrose was offered the chance to join the new study. “When I was told about the trial … I didn’t hesitate to join – what did I have to lose? It turned out to be a lifeline.
“Although I had to make biweekly trips from Suffolk to the hospital for the treatment, I had virtually no side-effects and was able to carry on as normal doing the things I love: sailing, cycling, and spending time with my family.”
Within about eight weeks of starting the treatment, scans revealed the tumour in his throat had been eradicated.
“When the research nurses called to tell me that, after two months, the tumour in my throat had completely disappeared, it was an amazing moment,” said Ambrose. “While there was still disease in my lungs at that point, the effect was staggering.”
He later underwent chemotherapy, followed by surgery. He currently has no evidence of disease.
“The treatment I’ve received at the Royal Marsden has been second to none and I’m so fortunate they’ve continued to find treatment that works for me – they’re the gift that keeps on giving,” said Ambrose. Last week he enjoyed a cruise off the coast of the UK with his wife, Sue.
The results of the trial show the immunotherapy combination enjoyed a particularly high success rate in a group of patients whose tumours had high levels of an immune marker called PD-L1.
Survival rates in those with high levels of PD-L1 who received the immunotherapy cocktail were the highest ever reported in a firstline therapy trial of relapsed or metastatic head and neck cancer.
These patients lived an average of three months longer than those having chemotherapy. The median overall survival for these patients was 17.6 months, the highest average ever reported in this group of patients.
Researchers said they hoped future findings from the CheckMate 651 trial, funded by Bristol Myers Squibb, will show further benefits of the therapy in patients with advanced head and neck cancers.
“Despite the lack of statistical significance, these results are clinically meaningful,” said Prof Kevin Harrington, professor of biological cancer therapies at the ICR and consultant clinical oncologist at the Royal Marsden, who led the CheckMate 651 trial. “We will need to do longer follow-up to see whether we can demonstrate a survival benefit across all patients in the trial.”
Health
WHO Demands Fresh Data from China amid Outbreak of Pneumonia in Children

The World Health Organization (WHO) is requesting more data from China amid an outbreak of pneumonia in children.
Dr Maria Van Kerkhove, a WHO epidemiologist, said the agency was ‘following up with China’ as hospitals across the country continue to be overwhelmed.
Face masks and social distancing are again being recommended in the country.
The country is said to be grappling with a spike in pneumonia, dubbed ‘white lung syndrome’ because of the way lung damage shows up on scans, among children that has been attributed to a rebound in respiratory illnesses rather than an entirely new virus.
China had one of the most brutal and longest lockdowns of any country in the world which the WHO says robbed children of vital immunity against seasonal illnesses.
Dr Van Kerkhove told the conference today: ‘Yes, we are seeing an increase in respiratory infections around the world.
‘We’re in autumn and entering winter months, so we are expecting to see rises in respiratory infections regardless.
We are following up with China. They are seeing an increase due a number of different infections
We are following up with our clinical network and following up with clinicians in China.
‘In terms of acute respiratory infections, we are looking at the burden on healthcare systems and looking at the healthcare capacities of systems.’
It comes after Chinese Health Ministry spokesman Mi Feng urged people in the country to again consider wearing face masks and distancing.
Speaking at a press conference on Sunday, he said: ‘Efforts should be made to increase the opening of relevant clinics and treatment areas, extend service hours and increase the supply of medicines.
‘It is necessary to do a good job in epidemic prevention and control in key crowded places.
‘[This includes] in schools, childcare institutions and nursing homes, and to reduce the flow of people and visits.’
Health
433 Foreign-Trained Doctors Fail MDCN Qualifying Exams

No fewer than 433 out of the 836 foreign-trained medical graduates who sat the qualifying examination organised by the Medical and Dental Council of Nigeria (MDCN) failed
The qualifying examination was held at the Aminu Kano Teaching Hospital between 22 and 23 November 2023.
The assessment for the foreign-trained medical graduates was in a Computer Based Test format with the graduates taking the examination in four different centres, namely: BMG Institute of Information Technology; JAMB Professional Test Centre; Kano Cooperative CBT Centre and Treztech, all in Kano State.
The examination comprises a computer-based test, a picture-based test, and an objective structural clinical examination.
Findings showed that most of the medical and dental graduates performed poorly in the CBT.
A list of shortlisted candidates in Abuja showed that a total of 836 candidates with medical degrees from foreign universities were selected for the examination initially. However, only 403 candidates passed, according to the results obtained on Monday.
Every year, thousands of Nigerians aspiring to become medical doctors and dentists enrol in foreign universities, spend a fortune on tuition and accommodation fees, and dedicate between four and seven years to pursuing the Bachelor of Medicine, Bachelor of Surgery course.
Among the favourite destinations for Nigerians studying medicine are Ukraine, Sudan, Cyprus, Egypt, The Caribbean, Russia, Belarus, India, Hungary, Guyana, Niger Republic, and Benin Republic. But on completion of their studies abroad, to get a licence to practise in Nigeria, they are required to pass the MDCN assessment.
The MDCN is the body that regulates the practice of Medicine, Dentistry, and Alternative Medicine in the country to safeguard the nation’s health care system.
The MDCN conducts the assessment twice a year.
The examination tests the candidates’ ability to apply their basic medical sciences and clinical skills in a healthcare setting.
Health
UK Confirms Never- Seen- Before Strain Of Swine Flu in Human

The UK’s first human case of swine flu strain H1N2, very similar to what has been circulating in pigs, has been detected, the UK Health Security Agency said on Monday.
Routine surveillance in general practitioner surgeries picked up the case after the person suffered a mild illness.
The UKHSA said it is now carrying out contact tracing to prevent further spread of the virus.
It is not known at this stage how transmissible the strain is or if there could be other cases in the UK.
It is also too early to say if the strain could have pandemic potential.
The UKHSA has notified the World Health Organisation of the latest case.
There have been about 50 reported human cases worldwide of the H1N2 virus since 2005, none of them related genetically to this strain.
The person involved is not known to have worked with pigs and has fully recovered.
The case was detected as part of routine national flu surveillance undertaken by UKHSA and the Royal College of GPs, which was in place even before the COVID-19 pandemic.
The patient was tested by their GP in North Yorkshire after experiencing respiratory symptoms.
The strain was identified via Polymerase Chain Reaction testing and genome sequencing.
The UKHSA said people with respiratory symptoms should continue to follow the existing guidance, avoiding contact with other people while suffering symptoms and taking particular care around vulnerable people and the elderly.
It said it was “monitoring the situation closely and is taking steps to increase surveillance within existing programmes involving GP surgeries and hospitals in parts of North Yorkshire.
“To assist in the detection of cases and assessment of transmission, those people who are contacted and asked to do the test are encouraged to do so.’’
Meera Chand, incident director at the UKHSA, said, “It is thanks to routine flu surveillance and genome sequencing that we have been able to detect this virus.
“This is the first time we have detected this virus in humans in the UK, though it is very similar to viruses that have been detected in pigs.
“We are working rapidly to trace close contacts and reduce any potential spread.
“In accordance with established protocols, investigations are underway to learn how the individual acquired the infection and to assess whether there are any further associated cases.’’
Chief veterinary officer, Christine Middlemiss, said, “We know that some diseases of animals can be transferred to humans, which is why high standards of animal health, welfare and biosecurity are so important.
Based on early information, the UKHSA said the strain detected in the UK differs from recent human cases of H1N2 elsewhere in the world but is similar to viruses in UK pigs.
In 2009, there was a pandemic in humans caused by flu strain H1N1, commonly referred to as swine flu.
NAN
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