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NHS England to offer breakthrough treatment for sickle cell disease

sickle cell

NHS England to offer breakthrough treatment for sickle cell disease

Thousands of patients in England are to benefit from the first treatment for sickle cell disease in two decades, the NHS has announced.

Crizanlizumab, a “revolutionary” life-changing drug treatment, is delivered by a transfusion drip and works by binding to a protein in the blood cells to prevent the restriction of blood and oxygen supply.

The therapy, the first to become available for the disease in 20 years, will help at least 5,000 people over the next three years, officials said.

Sickle cell disease – particularly common in people with an African or Caribbean background – is a serious and lifelong health condition. It can cause severe pain and organ failure, often requiring hospital admissions.

Current treatments to prevent sickle cell crises include a tablet called hydroxycarbamide and regular blood transfusions, but these are not always effective for people with severe forms of the disease.

“This is a historic moment for people with sickle cell disease who will be given their first new treatment in over two decades,” said Amanda Pritchard, chief executive of NHS England. “This revolutionary treatment will help to save lives, allow patients to have a better quality of life and reduce trips to A&E by almost half.”

People aged over 16 who suffer from multiple sickle cell crises every year will be eligible for the treatment. The disease is characterised by the production of unusually shaped red blood cells, which can cause serious health issues across the body, sending organs into crisis and causing extreme pain.

Sickle shaped cells can stick to blood vessel walls blocking the flow of oxygen to organs, causing excruciating pain episodes.
Toks Odesanmi, a sickle cell patient at Cambridge University hospitals trust, welcomed the arrival of the treatment and said it gave her new hope.

“Sickle cell disease has defined me, defined my body and made a big dent to my dreams,” said Odesanmi, 47, a finance specialist from Colchester. “No matter how hard I fight, it continues to defeat me. A new treatment brings hope and might make dreaming possible again.”

Sickle Cell Society chair Kye Gbangbola said: “A new treatment brings new hope for people living with sickle cell disorder, the world’s most common genetic blood condition. SCD is a medical emergency, it causes excruciating pain. This new treatment will reduce the number of agonising pain episodes we have to endure.

“The hope is improved quality of life for many living with the condition and their families.”

Health

Sierra Leone reports first case of monkeypox

Bayelsa confirms 13 monkeypox cases

Sierra Leone has reported its first confirmed case of mpox since the World Health Organization (WHO) raised its highest alert level for the potentially deadly viral disease last year.

According to the National Public Health Agency, the patient is a 27-year-old man from the rural district of the Western Zone, near the capital Freetown.

“Health teams are actively tracing and investigating to identify potentially exposed persons and to prevent further spread,” the agency announced in a social media post.

The confirmed case was detected on January 10, though health officials have not specified the variant affecting the patient.

Mpox, caused by a virus from the same family as smallpox, presents with high fever and skin lesions known as vesicles.

The disease was first identified in the Democratic Republic of Congo in 1970 and had mainly been limited to a dozen African countries before spreading more widely in 2022, including to regions where the virus had not previously circulated. The WHO declared its highest alert level for the disease in 2024.

In response, Sierra Leonean health authorities have swiftly activated containment measures. The infected patient has been placed in isolation while contacts will be monitored for 21 days. Surveillance efforts have been increased in all areas visited by the patient.

A public awareness campaign has been launched, and health workers are being equipped with protective gear and trained in prevention techniques to curb further spread.

Sierra Leone was previously one of the hardest-hit countries during the Ebola epidemic, which claimed around 4,000 lives, including nearly seven percent of the nation’s health workers, between 2014 and 2016.

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Risk of HMPV infection in Nigeria moderate- NCDC

The Nigeria Centre for Disease Control (NCDC) says the risk of the human metapneumovirus (HMPV) in the country is moderate.

HMPV, which was first reported in 2001 in the Netherlands, is a single-stranded ribonucleic acid (RNA) virus that causes symptoms similar to the common cold and influenza including cough, fever, nasal congestion, and fatigue, with an incubation period of three to six days.

It causes severe complications like pneumonia in infants, the elderly, and those with weakened immune systems and spreads through respiratory droplets or contact with contaminated surfaces.

China is currently experiencing an outbreak of the virus, sparking global concern. India has also reported at least two cases of the virus.

In an advisory issued, the NCDC said the agency, in collaboration with the ministry of health, is closely monitoring global developments. The agency said as of January 6, 2025, data from surveillance does not indicate any unusual increase in respiratory infections, including those caused by HMPV.

“However, given the global trends in HMPV cases, the Nigeria Centre for Disease Control and Prevention (NCDC) is proactively implementing measures to strengthen the country’s preparedness and response capacity.

In collaboration with the Federal Ministry of Health and partners such as the World Health Organization (WHO), the U.S. Centers for Disease Control and Prevention (USCDC), and the UK Health Security Agency (UKHSA), conducted a dynamic risk assessment for Human Metapneumovirus (HMPV).

The assessment classified the risk of HMPV for Nigeria as moderate. This evaluation will inform and guide preparedness efforts, decision-making, and response strategies to mitigate potential impacts.”

The NCDC said it is also collaborating with port health authorities to ensure robust preparedness at all international points of entry (PoEs).

“In addition, quarantine facilities are being identified and prepared to manage any suspected or confirmed cases if required. Infection Prevention and Control (IPC) materials are being deployed to PoEs to ensure adherence to hygiene and safety protocols. Information, Education, and Communication (IEC) materials are being developed and distributed to raise awareness and provide clear guidelines for frontline staff and travelers at PoEs.

The National Influenza Sentinel Surveillance (NISS) sites across the six geopolitical zones monitor Influenza-like Illness (ILI) and Severe Acute Respiratory Infections (SARI) which is already testing for COVID-19, will now also start testing for HMPV. Provisions will be made to increase the number of tests conducted. Additionally, laboratories in states with international airports will be supported to enable them to test for HMPV.”

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WHO declares new COVID outbreak in China global health emergency

The World Health Organization, WHO, has declared the outbreak of a new coronavirus in China, a global health emergency.

The WHO Director-General Tedros Ghebreyesus made the announcement at a press conference in Geneva.

WHO’s emergency committee on the epidemic had reportedly met Thursday afternoon and recommended designating the outbreak a Public Health Emergency of International Concern, PHEIC.

The decision had been “almost unanimous,” Didier Houssin, chair of the emergency committee, said at the press conference.

“The main reason for this declaration is not because of what is happening in China, but because of what is happening in other countries,” Tedros said at the press conference.

“Our greatest concern is the potential for the virus to spread to countries with weaker health systems and which are ill-prepared to deal with it. Let me be clear, this declaration is not a vote of no confidence in China. On the contrary, WHO continues to have confidence in China’s capacity to control the outbreak.”

Tedros also outlined recommendations made by the emergency committee to control the outbreak, including accelerating the development of vaccines and drugs and combatting the spread of misinformation.

This is the sixth time WHO has used that label, Public Health Emergency of International Concern, PHEIC. since the designation was introduced 15 years ago.

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