Health
No 10 to buy new antiviral treatments for Covid in time for winter
No 10 to buy new antiviral treatments for Covid in time for winter
No 10 has made deals to buy hundreds of thousands of doses of two new antiviral treatments for coronavirus, ministers have announced, at least one of which it is hoped will be approved for use in the UK ahead of the winter.
One deal covers 480,000 courses of molnupiravir, which can be taken as a pill twice a day. In trials, the drug, made by Merck, known as MSD outside the US, has been shown to cut the risk of hospitalisation or death for patients not in hospital by half.
The other treatment is PF-07321332/ritonavir, a combination of another oral antiviral treatment with ritonavir, a drug usually used to treat HIV/Aids. Made by Pfizer, the UK has a deal for 250,000 courses, the announcement said.
Neither treatment would be used in patients before approval by the Medicines and Healthcare products Regulatory Agency (MHRA); trials for PF-07321332/ritonavir are still under way. The supply of molnupiravir is expected to arrive no earlier than mid-November, with the Pfizer antivirals expected in late January.
Ministers and health advisers said the deals, made by the government’s antivirals taskforce, could play a significant role in reducing the extent of serious Covid cases over the winter. The health secretary, Sajid Javid, said they would form part of “an armoury of lifesaving measures to tackle the virus”.
Prof Jonathan Van-Tam, England’s deputy chief medical officer, said antivirals would be “particularly vital in protecting those who may not get the same antibody response to the vaccines as the majority of the population”. He added: “We will now work quickly to ensure the right cohorts of people receive these treatments as soon as possible, should they be approved by the MHRA.”
Health officials expect that most of the antivirals will be used to treat elderly people and immunocompromised individuals, who are most likely to be hospitalised with severe disease. The drugs work in different ways and could be used in combination in the future. The supplies are expected to last this winter and next.
Antivirals, which can be used to either treat those infected with a virus or protect people from becoming infected, have become an increasingly important part of the response to Covid. The health department says the first treatment used for Covid, dexamethasone – a steroid that dampens lung inflammation rather than an antiviral – has since saved 22,000 lives in the UK and about a million worldwide.
One key aim for the taskforce has been to find an antiviral pill that people can take at home before winter sets in.
Health
No new COVID-19 variant in Nigeria- FG
The Federal Government has clarified that the newly detected XEC COVID-19 variant, identified in Australia and some other countries in Europe, is not in Nigeria.
Ministry of Health and Social Welfare, Kachollum Daju confirmed that a recently leaked letter addressed to the Committee of Chief Medical Directors and Medical Directors was precautionary and not intended to cause panic.
Speaking further, Daju noted that the XEC COVID-19 variant has been detected in 29 countries, and due to the festive season, when travellers arrive from various parts of the world, it is crucial for hospitals to implement measures to ensure the country is not caught off guard.
In a letter dated December 5, 2024, the Federal Ministry of Health and Social Welfare, had urged health authorities to activate heightened alert systems across hospitals and maintain a high index of suspicion for patients with COVID-like symptoms.
The letter Signed by the Head of the Teaching Hospital Division, Dr O.N. Anuma, on behalf of the Permanent Secretary, the letter called for collaboration with relevant stakeholders to share critical data regarding the variant and implement enhanced monitoring protocols.
“I am directed to inform you of a newly detected XEC COVID-19 variant, which has been reported in Australia and has already spread to 29 countries globally.
“You may wish to know that this variant has shown a growth advantage over other circulating strains, raising concerns about its potential impact on public health,” the letter read.
“Alert systems should be immediately activated throughout our hospitals for high index of suspicion in patients with COVID-like symptoms.
“Timely information sharing among relevant stakeholders, including the Federal Ministry of Health, will be vital for effective response strategies.”
The Permanent Secretary stressed the importance of preventive measures during this period to prevent any potential spread of the variant into Nigeria.
Health
Oyo confirms 4 deaths in suspected Lassa fever outbreak
The Oyo State Rapid Response Team, on Thursday, confirmed four deaths linked to a suspected Lassa fever outbreak in the Saki West Local Government Area of the state.
A statement by the Commissioner for Information and Orientation, Dotun Oyelade, in Ibadan, the state capital, quoted his counterpart from the Ministry of Health, Oluwaserimi Ajetunmobi, saying the fatalities consisted three males and one 32-year-old female who was preparing for her marriage.
The report was that an owner of a hospital, alongside three others, died in the town mysteriously.
Following numerous calls reporting deaths in the town, the commissioner tasked the team to Saki to investigate.
“The background information gathered that one of the apprentices at the hospital who had returned from Iwajowa and fell ill about two weeks before the incident was suspected to have introduced the infection.
“She likely transmitted it to her co-workers and the hospital owner.
“Three of the deceased exhibited typical symptoms of Lassa fever, including craniofacial bleeding, while the hospital owner showed fatigue and self-medicated with antimalarials and antibiotics.
“His condition only prompted hospital admission when his self-treatment failed,” the statement read.
It added, “Extensive contact tracing was conducted, with particular focus on high-risk contacts who had been involved in the bathing and burial of the deceased.
“The hospital where all the deceased were associated was closed down for decontamination.
“The hospital that admitted the deceased health facility owner, without being informed of the deaths from an ‘unknown’ illness, was also shut down for decontamination, and the doctor was placed under surveillance.
“Public awareness campaigns were held to educate the community about Lassa fever, its transmission, symptoms, and preventive measures.
“The RRT provided on-the-job training to health workers in the affected areas to reinforce Infection Prevention Control protocols and prevent further spread of the disease.
“Sample collection was also carried out on a person exhibiting symptoms, pending laboratory confirmation. The line listing of contacts is still in progress, focusing on individuals at high risk”.
The government team also conducted an advocacy visit to the palace of the Okere of Saki, who was represented by his second-in-command, and was briefed on the outbreak and the necessary containment measures.
“Local government authorities within Saki West were equally informed and aligned with the efforts to manage the situation”, the statement added.
Investigation, according to the commissioner, also revealed that the outbreak initially involved the council, but had extended to Iwajowa and Kajola local government areas.
He said the State Disease Notification Officer in the respective areas had been instructed to begin preliminary containment efforts while awaiting the full deployment of the State RRT.
The team, comprising the Director of Public Health, the State Epidemiologist, DSNOs, State Laboratory Focal Persons, representatives from the World Health Organisation and Red Cross, as well as the PHC Coordinator of Saki West and the LGA DSNO, embarked on a comprehensive investigation to the scene of the incidence.
Health
NCDC issues public advisory on Lassa Fever, warns of increased spread
The Nigeria Centre for Disease Control and Prevention, NCDC has issued a public health advisory on Lassa fever warning of increased case detection and spread of the viral infection.
The Director General of the NCDC, Dr Jide Idris, raised the concerns following increased reporting of the outbreak by its surveillance teams across the country.
At a press briefing in Abuja, Dr Idris said the death toll from Lassa Fever in Nigeria has risen to 174 out of 1,035 confirmed cases across 28 states and 129 LGAs as of October 13, 2024.
”Lassa fever outbreaks are highly virulent and the loss of human lives resulting from disease are not just statistics but represent the death of beloved family members, spouses and parents.
”In 2022, Nigeria reported 1,067 confirmed cases across 27 states and 112 LGAs. In 2023, 28 states and 114 LGAs reported confirmed cases, with 9,155 suspected cases, 1,270 confirmed cases, and 227 deaths.
”While we continue to intensify efforts using an all-of-society approach, the public is hereby advised to note that the virus spreads through direct contact with urine, faeces, saliva, or blood of infected rats. Contact with objects, household items, and surfaces contaminated with the urine, faeces, saliva, or blood of infected rats.
”Consuming food or water contaminated with the urine, faeces, saliva, or blood of infected rats or person-to-person transmission through body fluids of an infected person.
Dr Idris also warned health care professionals to be alert as Lassa fever presents like other common illnesses accompanied by fever, headache, general body weakness, cough, nausea, vomiting,
While noting that early diagnosis and treatment of the disease greatly increase the chances of patient survival, Dr Idris highlighted the economic cost of Lassa Fever to communities and the healthcare system.
”The disease is also associated with significant loss of livelihood in the communities it ravages. Heads of households are unable to work when exposed to Lassa fever and when other household members are infected, the cost of care and treatment of the disease strains existing household income pushing households toward poverty.
”Healthcare workers are also vulnerable and the loss of experienced medical personnel due to infection further strains the country’s limited healthcare workforce.”
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