Health

Offshoot of Covid Delta variant on the rise in England

A newly detected coronavirus variant is on the rise in England, with the virus believed to be an offshoot of Delta.

According to a briefing from the UK Health Security Agency, released on Friday, “a Delta sublineage newly designated as AY.4.2 is noted to be expanding in England”, with the body adding that the variant is being monitored and assessed.

The report states that in the week beginning 27 September – the last week for which complete sequencing data was available – AY.4.2 accounted for about 6% of sequenced coronavirus cases and is “on an increasing trajectory”.

AY.4.2 contains two mutations in its spike protein, called A222V and Y145H. The spike protein sits on the outside of the coronavirus and helps the virus to enter cells.

However, Ravi Gupta, a professor of clinical microbiology at the University of Cambridge, told the Guardian these mutations were not of particular concern. “A222V has been seen in other lineages of Delta,” he said. “It doesn’t have a really large effect on the virus.”

Gupta added similar mutations to Y145H had been seen in the Alpha variant and other variants. While these appear to have an effect on the binding between antibodies and the virus, Gupta said the effect was, at most, modest.

“But in my mind, these are not really significant mutations,” he said. “We need to look further at what the non-spike mutations are.”

In the past, new Covid variants have fuelled large surges in the number of cases – the Alpha variant played a key role in rising cases last winter, while the Delta variant took off and led to sharp increases in the spring. Daily Covid cases in England are rising once again: 39,624 new Covid cases were reported on Saturday, the highest figure since late July.

According to the Financial Times, Dr Jeffrey Barrett, the director of the Covid-19 Genomics Initiative at the Wellcome Sanger Institute in Cambridge, and Prof Francois Balloux, the director of the University College London Genetics Institute, have suggested AY.4.2 could be 10-15% more transmissible than the original Delta variant.

However, they urged caution. “Britain is the only country in which it has taken off in this way and I still would not rule out its growth being a chance demographic event,” Balloux told the FT.

Balloux told the Guardian the new variant was unlikely to be behind the recent rise in cases.

“Its potential higher transmissibility could at this stage only explain a tiny fraction of additional cases,” he said. “It’s around 10% frequency [now], and assuming it may be 10% more transmissible, that would only explain an additional 1% extra infections [every five or so days].”

Gupta said the focus on a new variant was missing the point, noting a number of other important factors including the slow rollout of jabs to older children. According to official figures, vaccination rates among 12- to 15-year-olds were about three times lower in England than Scotland.

“We shouldn’t be blaming the virus for what is going on in the UK,” said Gupta. “It is because we have fundamentally failed to control transmission, and that is because kids are vulnerable, they have not been vaccinated, they are back at school, they are spreading virus among themselves and they are feeding it into their families.”

All this, he added, was happening with Delta dominant, which research had shown had greater ability to evade an immune response than the Alpha variant.

“It breaks through the vaccines anyway, so vaccines protect you partially from an infection being transmitted but it is not complete protection,” he said. “So the message needs to be, let’s stop worrying about mutations and worry about the fact we have uncontrolled transmission in the UK.”

Health

WHO Demands Fresh Data from China amid Outbreak of Pneumonia in Children

The World Health Organization (WHO) is requesting more data from China amid an outbreak of pneumonia in children.

Dr Maria Van Kerkhove, a WHO epidemiologist, said the agency was ‘following up with China’ as hospitals across the country continue to be overwhelmed.

Face masks and social distancing are again being recommended in the country.

The country is said to be grappling with a spike in pneumonia, dubbed ‘white lung syndrome’ because of the way lung damage shows up on scans, among children that has been attributed to a rebound in respiratory illnesses rather than an entirely new virus.

China had one of the most brutal and longest lockdowns of any country in the world which the WHO says robbed children of vital immunity against seasonal illnesses.

Dr Van Kerkhove told the conference today: ‘Yes, we are seeing an increase in respiratory infections around the world.

‘We’re in autumn and entering winter months, so we are expecting to see rises in respiratory infections regardless.

We are following up with China. They are seeing an increase due a number of different infections

We are following up with our clinical network and following up with clinicians in China.

‘In terms of acute respiratory infections, we are looking at the burden on healthcare systems and looking at the healthcare capacities of systems.’

It comes after Chinese Health Ministry spokesman Mi Feng urged people in the country to again consider wearing face masks and distancing.

Speaking at a press conference on Sunday, he said: ‘Efforts should be made to increase the opening of relevant clinics and treatment areas, extend service hours and increase the supply of medicines.

‘It is necessary to do a good job in epidemic prevention and control in key crowded places.

‘[This includes] in schools, childcare institutions and nursing homes, and to reduce the flow of people and visits.’

Health

433 Foreign-Trained Doctors Fail MDCN Qualifying Exams

No fewer than 433 out of the 836 foreign-trained medical graduates who sat the qualifying examination organised by the Medical and Dental Council of Nigeria (MDCN) failed

The qualifying examination was held at the Aminu Kano Teaching Hospital between 22 and 23 November 2023.

The assessment for the foreign-trained medical graduates was in a Computer Based Test format with the graduates taking the examination in four different centres, namely: BMG Institute of Information Technology; JAMB Professional Test Centre; Kano Cooperative CBT Centre and Treztech, all in Kano State.

The examination comprises a computer-based test, a picture-based test, and an objective structural clinical examination.

Findings showed that most of the medical and dental graduates performed poorly in the CBT.

A list of shortlisted candidates in Abuja showed that a total of 836 candidates with medical degrees from foreign universities were selected for the examination initially. However, only 403 candidates passed, according to the results obtained on Monday.

Every year, thousands of Nigerians aspiring to become medical doctors and dentists enrol in foreign universities, spend a fortune on tuition and accommodation fees, and dedicate between four and seven years to pursuing the Bachelor of Medicine, Bachelor of Surgery course.

Among the favourite destinations for Nigerians studying medicine are Ukraine, Sudan, Cyprus, Egypt, The Caribbean, Russia, Belarus, India, Hungary, Guyana, Niger Republic, and Benin Republic. But on completion of their studies abroad, to get a licence to practise in Nigeria, they are required to pass the MDCN assessment.

The MDCN is the body that regulates the practice of Medicine, Dentistry, and Alternative Medicine in the country to safeguard the nation’s health care system.

The MDCN conducts the assessment twice a year.

The examination tests the candidates’ ability to apply their basic medical sciences and clinical skills in a healthcare setting.

Health

UK Confirms Never- Seen- Before Strain Of Swine Flu in Human

The UK’s first human case of swine flu strain H1N2, very similar to what has been circulating in pigs, has been detected, the UK Health Security Agency said on Monday.

Routine surveillance in general practitioner surgeries picked up the case after the person suffered a mild illness.

The UKHSA said it is now carrying out contact tracing to prevent further spread of the virus.

It is not known at this stage how transmissible the strain is or if there could be other cases in the UK.

It is also too early to say if the strain could have pandemic potential.

The UKHSA has notified the World Health Organisation of the latest case.

There have been about 50 reported human cases worldwide of the H1N2 virus since 2005, none of them related genetically to this strain.

The person involved is not known to have worked with pigs and has fully recovered.

The case was detected as part of routine national flu surveillance undertaken by UKHSA and the Royal College of GPs, which was in place even before the COVID-19 pandemic.

The patient was tested by their GP in North Yorkshire after experiencing respiratory symptoms.

The strain was identified via Polymerase Chain Reaction testing and genome sequencing.

Related News

The UKHSA said people with respiratory symptoms should continue to follow the existing guidance, avoiding contact with other people while suffering symptoms and taking particular care around vulnerable people and the elderly.

It said it was “monitoring the situation closely and is taking steps to increase surveillance within existing programmes involving GP surgeries and hospitals in parts of North Yorkshire.

“To assist in the detection of cases and assessment of transmission, those people who are contacted and asked to do the test are encouraged to do so.’’

Meera Chand, incident director at the UKHSA, said, “It is thanks to routine flu surveillance and genome sequencing that we have been able to detect this virus.

“This is the first time we have detected this virus in humans in the UK, though it is very similar to viruses that have been detected in pigs.

“We are working rapidly to trace close contacts and reduce any potential spread.

“In accordance with established protocols, investigations are underway to learn how the individual acquired the infection and to assess whether there are any further associated cases.’’

Chief veterinary officer, Christine Middlemiss, said, “We know that some diseases of animals can be transferred to humans, which is why high standards of animal health, welfare and biosecurity are so important.

Based on early information, the UKHSA said the strain detected in the UK differs from recent human cases of H1N2 elsewhere in the world but is similar to viruses in UK pigs.

In 2009, there was a pandemic in humans caused by flu strain H1N1, commonly referred to as swine flu.

NAN