Health

Women under 35 face higher risk of breast cancer spreading – study

Women diagnosed with breast cancer under the age of 35 face a higher risk of it spreading, according to the first global study of its kind.

Breast cancer is the most common form of cancer, with 2.3 million people diagnosed every year. Survival rates are generally good, which is largely because of screening, early diagnosis and improved treatment.

However, until now, little has been known about the risk of secondary breast cancer, where the disease spreads to other parts of the body and becomes incurable.

A meta analysis of more than 400 studies has found the risk of breast cancer spreading to another part of the body ranges from 6% to 22%. The results of the study are being presented at the sixth International Consensus Conference for Advanced Breast Cancer .

The findings also suggest certain women face a higher risk, including those diagnosed with breast cancer under the age of 35, those with larger tumours when initially diagnosed and those with specific types of the disease, for example luminal B.

Kotryna Temcinaite, senior research communications manager at the charity Breast Cancer Now, said the analysis “provides helpful insight into who is most at risk”.

“About 1,000 women in the UK die each month from incurable secondary breast cancer,” she said. “We desperately need to learn more about this devastating disease so that we can find new ways to improve treatment, care and support for people living with it, and for those living in fear of a diagnosis.

“The data shows that people diagnosed with primary breast cancer aged 35 years or younger have the greatest chance of developing secondary breast cancer. The study also highlights that the size of the tumour, the type of breast cancer and the length of time since primary diagnosis can impact a person’s risk.

“Secondary breast cancer can develop many years after an initial cancer diagnosis, so it’s vital that we understand it better and find new ways to prevent it.”

For the study, researchers analysed data on tens of thousands of women across more than 400 studies from North and South America, Europe, Africa, Asia and Oceania.

The analysis suggests the overall risk of metastasis for most breast cancer patients is between 6% and 22%. Researchers say the range is broad because the risk varies significantly depending on a whole range of different factors.

For example, women first diagnosed under the age of 35 have a 12.7% to 38% risk of their breast cancer coming back and spreading to other parts of the body, while women aged 50 years or older have a risk of 3.7% to 28.6%.

“This may be because younger women have a more aggressive form of breast cancer or because they are being diagnosed at a later stage,” said the presenter of the study, Dr Eileen Morgan, of the International Agency for Research on Cancer (IARC).

“Breast cancer is the most common form of cancer in the world,” she said. “Most women are diagnosed when their cancer is confined to the breast or has only spread to nearby tissue. But in some women, the cancer will grow and spread to other parts of the body or come back in a different part of the body several years after the end of their initial treatment.

“At this point the cancer becomes much harder to treat and the risk of dying is higher. However, we don’t really know how many people develop metastatic breast cancer because cancer registries have not been routinely collecting this data.”

The study also found women with specific types of breast cancer appeared to have a higher risk of it spreading, for example those with a type of cancer called luminal B.

Those with this form had a 4.2% to 35.5% risk of it spreading compared with 2.3% to 11.8% risk in women diagnosed with luminal A cancer.

Dr Shani Paluch-Shimon, a member of the conference’s scientific committee and director of the breast unit at Hadassah University hospital in Israel, who was not involved with the research, said the findings were “vital” for patients and doctors.

Health

WHO Demands Fresh Data from China amid Outbreak of Pneumonia in Children

The World Health Organization (WHO) is requesting more data from China amid an outbreak of pneumonia in children.

Dr Maria Van Kerkhove, a WHO epidemiologist, said the agency was ‘following up with China’ as hospitals across the country continue to be overwhelmed.

Face masks and social distancing are again being recommended in the country.

The country is said to be grappling with a spike in pneumonia, dubbed ‘white lung syndrome’ because of the way lung damage shows up on scans, among children that has been attributed to a rebound in respiratory illnesses rather than an entirely new virus.

China had one of the most brutal and longest lockdowns of any country in the world which the WHO says robbed children of vital immunity against seasonal illnesses.

Dr Van Kerkhove told the conference today: ‘Yes, we are seeing an increase in respiratory infections around the world.

‘We’re in autumn and entering winter months, so we are expecting to see rises in respiratory infections regardless.

We are following up with China. They are seeing an increase due a number of different infections

We are following up with our clinical network and following up with clinicians in China.

‘In terms of acute respiratory infections, we are looking at the burden on healthcare systems and looking at the healthcare capacities of systems.’

It comes after Chinese Health Ministry spokesman Mi Feng urged people in the country to again consider wearing face masks and distancing.

Speaking at a press conference on Sunday, he said: ‘Efforts should be made to increase the opening of relevant clinics and treatment areas, extend service hours and increase the supply of medicines.

‘It is necessary to do a good job in epidemic prevention and control in key crowded places.

‘[This includes] in schools, childcare institutions and nursing homes, and to reduce the flow of people and visits.’

Health

433 Foreign-Trained Doctors Fail MDCN Qualifying Exams

No fewer than 433 out of the 836 foreign-trained medical graduates who sat the qualifying examination organised by the Medical and Dental Council of Nigeria (MDCN) failed

The qualifying examination was held at the Aminu Kano Teaching Hospital between 22 and 23 November 2023.

The assessment for the foreign-trained medical graduates was in a Computer Based Test format with the graduates taking the examination in four different centres, namely: BMG Institute of Information Technology; JAMB Professional Test Centre; Kano Cooperative CBT Centre and Treztech, all in Kano State.

The examination comprises a computer-based test, a picture-based test, and an objective structural clinical examination.

Findings showed that most of the medical and dental graduates performed poorly in the CBT.

A list of shortlisted candidates in Abuja showed that a total of 836 candidates with medical degrees from foreign universities were selected for the examination initially. However, only 403 candidates passed, according to the results obtained on Monday.

Every year, thousands of Nigerians aspiring to become medical doctors and dentists enrol in foreign universities, spend a fortune on tuition and accommodation fees, and dedicate between four and seven years to pursuing the Bachelor of Medicine, Bachelor of Surgery course.

Among the favourite destinations for Nigerians studying medicine are Ukraine, Sudan, Cyprus, Egypt, The Caribbean, Russia, Belarus, India, Hungary, Guyana, Niger Republic, and Benin Republic. But on completion of their studies abroad, to get a licence to practise in Nigeria, they are required to pass the MDCN assessment.

The MDCN is the body that regulates the practice of Medicine, Dentistry, and Alternative Medicine in the country to safeguard the nation’s health care system.

The MDCN conducts the assessment twice a year.

The examination tests the candidates’ ability to apply their basic medical sciences and clinical skills in a healthcare setting.

Health

UK Confirms Never- Seen- Before Strain Of Swine Flu in Human

The UK’s first human case of swine flu strain H1N2, very similar to what has been circulating in pigs, has been detected, the UK Health Security Agency said on Monday.

Routine surveillance in general practitioner surgeries picked up the case after the person suffered a mild illness.

The UKHSA said it is now carrying out contact tracing to prevent further spread of the virus.

It is not known at this stage how transmissible the strain is or if there could be other cases in the UK.

It is also too early to say if the strain could have pandemic potential.

The UKHSA has notified the World Health Organisation of the latest case.

There have been about 50 reported human cases worldwide of the H1N2 virus since 2005, none of them related genetically to this strain.

The person involved is not known to have worked with pigs and has fully recovered.

The case was detected as part of routine national flu surveillance undertaken by UKHSA and the Royal College of GPs, which was in place even before the COVID-19 pandemic.

The patient was tested by their GP in North Yorkshire after experiencing respiratory symptoms.

The strain was identified via Polymerase Chain Reaction testing and genome sequencing.

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The UKHSA said people with respiratory symptoms should continue to follow the existing guidance, avoiding contact with other people while suffering symptoms and taking particular care around vulnerable people and the elderly.

It said it was “monitoring the situation closely and is taking steps to increase surveillance within existing programmes involving GP surgeries and hospitals in parts of North Yorkshire.

“To assist in the detection of cases and assessment of transmission, those people who are contacted and asked to do the test are encouraged to do so.’’

Meera Chand, incident director at the UKHSA, said, “It is thanks to routine flu surveillance and genome sequencing that we have been able to detect this virus.

“This is the first time we have detected this virus in humans in the UK, though it is very similar to viruses that have been detected in pigs.

“We are working rapidly to trace close contacts and reduce any potential spread.

“In accordance with established protocols, investigations are underway to learn how the individual acquired the infection and to assess whether there are any further associated cases.’’

Chief veterinary officer, Christine Middlemiss, said, “We know that some diseases of animals can be transferred to humans, which is why high standards of animal health, welfare and biosecurity are so important.

Based on early information, the UKHSA said the strain detected in the UK differs from recent human cases of H1N2 elsewhere in the world but is similar to viruses in UK pigs.

In 2009, there was a pandemic in humans caused by flu strain H1N1, commonly referred to as swine flu.

NAN